Immunopathology In Toxicology And Drug Development: Volume 2, Organ Systems

Download Immunopathology In Toxicology And Drug Development: Volume 2, Organ Systems

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays.

These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Oral Bioavailability Assessment: Basics And Strategies For Drug Discovery And Development

Download Oral Bioavailability Assessment: Basics And Strategies For Drug Discovery And Development

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability one of the most significant hurdles in drug discovery and development.

Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability

Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development

Explains how preclinical animal models used in preclinical testing and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development

Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)

Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

Working With Coders: A Guide To Software Development For The Perplexed Non-techie

Download Working With Coders: A Guide To Software Development For The Perplexed Non-techie

Get introduced to the fascinating world inhabited by the professional software developer. Aimed at a non-technical audience, this book aims to de-obfuscate the jargon, explain the various activities that coders undertake, and analyze the specific pressures, priorities, and preoccupations that developers are prone to. In each case it offers pragmatic advice on how to use this knowledge to make effective business decisions and work productively with software teams.

Software projects are, all too often, utter nightmares for everyone involved. Depending on which study you read, between 60 and 90 percent of all software projects are completed late, run over budget, or deliver an inferior quality end product. This blight affects everyone from large organizations trying to roll out business change to tiny startups desperately trying to launch their MVP before the money runs out. While there has been much attention devoted to understanding these failings, leading to the development of entire­ management methodologies aimed at reducing the failure rate, such new processes have had, at best, limited success in delivering better results.

Based on a decade spent exploring the world of software, Patrick Gleeson argues that the underlying reason for the high failure rate of software projects is that software development, being a deeply arcane and idiosyncratic process, tends to be thoroughly and disastrously misunderstood by managers and leaders. So long as the people tasked with making decisions about software projects are unaware of these idiosyncrasies and their ramifications, software projects will be delivered late, software products will be unfit for purpose, and relations between software developers and their non-technical colleagues will be strained. Even the most potent modern management tools are ineffective when wielded blindly.

To anyone who employs, contracts, manages, or works with software developers, Working with Coders: A Guide to Software Development for the Perplexed Non-Techie delivers the understanding necessary to reduce friction and inefficiencies at the intersection between software development teams and their non-technical colleagues.

What You'll Learn

Discover why software projects are so commonly delivered late and with an abysmal end product

Examine why the relationship between coders and their non-technical colleagues is often strained

Understand how the software development process works and how to support it effectively

Decipher and use the jargon of software development

Keep a team of coders happy and improve the odds of successful software project delivery

Who This Book Is For

Anyone who employs, contracts, or manages software developers―such as tech startup CEOs, project managers, and clients of digital agencies―and wishes the relationship were easier and more productive. The secondary readership is software developers who want to find ways of working more effectively as part of a team.

Beginner's Guide To Android App Development: A Practical Approach For Beginners

Download Beginner's Guide To Android App Development: A Practical Approach For Beginners

This book covers Android app design fundamentals in Android Studio using Java programming language.

The author assumes you have no experience in app development. The book starts with the installation of the required development environment and setting up the emulators. Then, the simplest “Hello World” app is developed step by step. In the next chapter, basics of the Java programming language are given with practical examples. Screenshots and code snippets are clearly given in the book to guide the reader. After the Java lecture, 7 complete Android apps are developed again by step by step instructions. Each code line is explained. As the reader follows the development of the example apps, he/she will learn designing user interfaces, connecting interface objects to code, developing efficient Java code and testing the app on emulators and real devices.

The last chapter explains the installation of the Unity game engine, developing a simple 2D platform game in Unity, setting up touch controls for Android environment and exporting the game as a standalone .apk file ready to be installed on Android devices.

Sample apps developed in this book are as follows:

1. Headlight app: Learn the basics of app development and use buttons in your code.

2. Body mass index (BMI) calculator app: Using input boxes, performing calculations and displaying the results on the screen.

3. Simple dice roller app: Using random number generator functions, including images in your project, displaying images on the screen and changing the displayed image programmatically.

4. The compass app: Accessing the magnetic field sensor, setting required permissions, extracting the direction angle and animating a compass figure.

5. Show my location app: Creating a map project, setting required permissions, accessing GPS device and showing real time location on the map.

6. S.O.S. sender app: Adding SMS functionality, setting required permissions and sending real time location using SMS.

7. Development of a 2D platform game: Installing Unity game engine, developing the visual part of the game, implementing the game logic in the code, setting up touch controls and exporting the game as a standalone .apk file.

This book includes 237 figures and 130 code snippets that are used to explain app development concepts clearly. Full resolution colour figures and complete project files can be downloaded from the book's companion website:

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Building Bots With Microsoft Bot Framework

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Key Features

Develop various real-world intelligent bots from scratch using Microsoft Bot Framework

Integrate your bots with most popular conversation platforms such as Skype, Slack, and Facebook Messenger

Flaunt your bot building skills in your organization by thoroughly understanding and implementing the bot development concepts such as messages (rich text and pictures), dialogs, and third-party authentication and calling

Book Description

This book starts with setting up the Microsoft Bot Framework development environment and emulator, and quickly moves on to building the first bot using Connector and Builder SDK. You will explore how to register, connect, test, and publish your bot to the Slack, Skype, and Facebook Messenger platforms.

Throughout this book, you will build different types of bots from simple to complex as you progress, such as a weather bot, a natural speech and intent processing bot, an Interactive Voice Response (IVR) bot for a bank, a facial expression recognition bot, and more from scratch.

These bots were designed and developed to teach you concepts such as text detection, implementing LUIS dialogs, Cortana Intelligence Services, third-party authentication, Rich Text format, Bot State Service, and MicroServices so you can practice working with the standard development tools such as Visual Studio, Bot Emulator, and Azure.

What you will learn

Set up a development environment and install all the required software to get started programming a bot

Publish a bot to Slack, Skype, and the Facebook Messenger platform

Develop a fully functional weather bot that communicates the current weather in a given city

Help your bot identify the intents of a text with the help of LUIS, in order to make decisions

Integrate an API into your bot development

Build an IVR solution

Explore the concept of MicroServices and see how MicroServices can be used in bot development

Develop an IoT project, deploy it, and connect it to a bot

Programming Microsoft Dynamics Nav - Fifth Edition

Download Programming Microsoft Dynamics Nav - Fifth Edition

Customize your NAV applications

About This Book

Gain from the insights and methods of industry-leading experts and tailor your applications to best suit the needs of your business

Learn through the detailed explanations and useful examples that are presented in a logical, step-by-step manner

This comprehensive guide is written with the goals of being used as a classroom text, a self-study text, and as a handy in-depth reference guide

Who This Book Is For

This book will appeal to all those who want to learn about NAV's powerful and extensive built-in development capabilities. It assumes that you understand programming and are familiar with business application software, although you aren't expected to have worked with NAV before. ERP consultants and managers of NAV development will also find the book helpful.

What You Will Learn

Productively and effectively use the development tools that are built into Dynamics NAV

Understand the strengths of NAV's development tools and how they can be applied to address functional business requirements

Introduction to programming using the C/AL language in the C/SIDE Development Environment

Explore functional design and development using C/AL

Leverage advanced NAV development features and tools

Get to know the best practices to design and develop modifications of new functionality integrated with the standard NAV software

In Detail

Microsoft Dynamics NAV is a full business solution suite, and a complete ERP solution, which contains a robust set of development tools to support customization and enhancement. These tools help in greater control over financials and can simplify supply chain, manufacturing, and operations.

This book will take you from an introduction to Dynamics NAV and its integrated development tools to being a productive developer in the Dynamics NAV Development Environment. You will find this book very useful if you want to evaluate the product's development capabilities or need to manage Dynamics NAV based projects. It will teach you about the NAV application structure, the C/SIDE development environment, the C/AL language paired with the improved editor, the construction and uses of each object type, and how it all fits together to build universal applications. With this new edition, you will be able to understand how to design and develop using Patterns and new features such as Extensions and Events.

Style and approach

This book is filled with examples and will serve as a comprehensive reference guide, complementing NAV's Help files.

Mastering Typescript - Second Edition

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Key Features Start with the basics, then enhance your knowledge with in-depth discussions on language features, third-party libraries, design patterns and more Practical examples that show how to use TypeScript with popular frameworks, including Backbone, Angular 2, React, Aurelia, Node and others Focus on test-driven development to build high quality applications that are modular, scalable and adaptable Book Description The TypeScript language, compiler and open-source development toolset brings JavaScript development up to the enterprise level. It allows us to use ES5, ES6 and ES7 JavaScript language features today - including classes, interfaces, generics, modules and more. It's simple typing syntax enables building large, robust applications using object-oriented techniques and industry standard design principles. Packed with practical, real-world examples, this book is a guide to bringing the benefits of strongly typed, object-oriented programming and design principles into the JavaScript development space. Starting with core language features, and working through more advanced topics such as generics and asynchronous programming techniques, you will learn how to gain maximum benefit from your JavaScript development with TypeScript. With a strong focus on test-driven development, and coverage of many popular and in-demand JavaScript frameworks, you can fast-track your TypeScript knowledge to a professional level. By the end of this book, you will be able to confidently build TypeScript applications, whether you are targeting Angular 2, Aurelia, React, Backbone, Node or any other JavaScript framework. What you will learn Gain an insight into core and advanced TypeScript language features including inheritance, generics, asynchronous programming techniques, promises, decorators and more Integrate your existing JavaScript libraries and third-party frameworks by writing and using declaration files Target popular JavaScript frameworks such as jQuery, Backbone, Angular 2, Aurelia, React, Node and Express Create extensive test suites for your application, including unit testing, integration testing and browser automation with Jasmine, Protactor and Selenium Organize your application code using modules, AMD loaders, Require and SystemJs Explore advanced object-oriented design principles including Dependency Injection and Domain Events Understand and compare the various MVC implementations in Aurelia, Angular 2 and React Build a complete single-page web application that incorporates css animations to enhance your customer's browsing experience

An Introduction To Html5 Game Development With Phaser.js

Download An Introduction To Html5 Game Development With Phaser.js

Experience the thrill of crafting your own HTML5 game with Phaser.js game engine. HTML5 and modern JavaScript game engines have helped revolutionized web based games. Each chapter in An Introduction to HTML5 Game Development with Phaser.js showcases a sample game that illustrates an aspect of Phaser.js (now Lazer.js) that can be used as is, or in remixed games of the developer’s design. Each of these examples help the reader to understand how to optimize JavaScript game development with modern project tooling like Grunt and Bower. Though the world of HTML game development continues to grow and evolve, An Introduction to HTML5 Game Development with Phaser.js, provides a grounded resource and vital learning tool to anyone looking to optimize web game development process.

Type-driven Development With Idris

Download Type-driven Development With Idris

Type-Driven Development with Idris, written by the creator of Idris, teaches you how to improve the performance and accuracy of your programs by taking advantage of a state-of-the-art type system. This book teaches you with Idris, a language designed to support type-driven development.

Purchase of the print book includes a free eBook in PDF, Kindle, and ePub formats from Manning Publications.

About the Technology

Stop fighting type errors! Type-driven development is an approach to coding that embraces types as the foundation of your code - essentially as built-in documentation your compiler can use to check data relationships and other assumptions. With this approach, you can define specifications early in development and write code that's easy to maintain, test, and extend. Idris is a Haskell-like language with first-class, dependent types that's perfect for learning type-driven programming techniques you can apply in any codebase.

About the Book

Type-Driven Development with Idris teaches you how to improve the performance and accuracy of your code by taking advantage of a state-of-the-art type system. In this book, you'll learn type-driven development of real-world software, as well as how to handle side effects, interaction, state, and concurrency. By the end, you'll be able to develop robust and verified software in Idris and apply type-driven development methods to other languages.

What's Inside

Understanding dependent types

Types as first-class language constructs

Types as a guide to program construction

Expressing relationships between data

About the Reader

Written for programmers with knowledge of functional programming concepts.

About the Author

Edwin Brady leads the design and implementation of the Idris language.

Test-driven Development With Python, 2nd Edition [early Release]

Download Test-driven Development With Python, 2nd Edition [early Release]

By taking you through the development of a real web application from beginning to end, the updated second edition of this hands-on guide demonstrates the practical advantages of test-driven development (TDD) with Python. You’ll learn how to write and run tests before building each part of your app, and then develop the minimum amount of code required to pass those tests. The result? Clean code that works.

Author Harry J.W. Percival uses a concrete example—the development of a web site, from scratch—to teach TDD methodology and how it applies to web programming, from the basics of database integration and Javascript to more advanced topics such as mocking, Ajax, and REST APIs. It's ideal for relative newcomers and self-taught web developers looking to take their skills to the next level with a more structured approach.

Sustainable Development And Tropical Agri-chains

Download Sustainable Development And Tropical Agri-chains

This book links tropical agri-chain dynamics – with which CIRAD and AFD have been involved for decades – to that of sustainable development. Increased environmental and social concerns urge agri-chain actors and development practitioners to design innovations, and public and private actors to invent regulations in connection with agri-chains to improve sustainability. With a view to contributing towards implementing the Sustainable Development Goals (SDGs), this book examines the different roles of agri-chains: as vectors of development, as spaces of innovation, as objects of evaluation, and as arenas of regulation. It builds upon the findings and experiences of CIRAD and its researchers together with their Southern partners, and of AFD and its officers. Linking agricultural production with the other economic sectors, agri- chains are key spaces where local and global challenges to sustainability meet and where local and global actors experiment interlinked or common solutions.