Looking for an imaging solution that can produce a resolution that is far beyond ultrasound and comparable to MRI or CT, but with a small, relatively low-cost device that fits a handheld scanner? Photoacoustic (PA) imaging is uniquely suited to this situation thanks to its superior tissue-penetration depth and good spatial resolution. This Spotlight summarizes recent progress in the surface modification and application of carbon nanoparticles as PA contrast agents. Carbon-based contrast agents are expected to have great potential in basic biomedical research and clinical diagnostic applications.
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